Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling\ncascades with other intracellular pathways in breast cancer could lead to massive abnormal\nsignaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles\nin cancer development would give a promising therapeutics strategy in combating the disease.\nGenetic manipulations through siRNAs targeting the complementary sequence of the oncogenic\nmRNA in breast cancer is one of the promising approaches that can be harnessed to develop more\nefficient treatments for breast cancer. In this review, we highlighted the effects of major signaling\npathways stimulated by oncogene products on breast tumorigenesis and discussed the potential\ntherapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the\nstimulated signaling pathways.
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